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Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

But it represents the direction the clinical research is moving

2018 Jul Luciana Moine, Mara Rivoira, Gabriela Daz de Barboza, Adriana Prez, Nori Tolosa de Talamoni

Administration less frequent than twice weekly likely allows complete dissipation of synaptic changes between doses, preventing the cumulative structural modifications that constitute Dihexas therapeutic mechanism